Oxantel Pamoate

Research use only, not for human use.

Oxantel pamoate is used as Antinematodal Agent.

Oxantel pamoate is used as Antinematodal Agent.(In Vivo):The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED50s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED50s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus.

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The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED50s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED50s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus.

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Others

Other Targets

Antiparasitic

Infection

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68813-55-8

604.65

C36H32N2O7

>98% (HPLC)

DMSO: 10 mM

CN1CCCN=C1C=CC1=CC(O)=CC=C1.CN1CCCN=C1C=CC1=CC(O)=CC=C1.OC(=O)C1=C(CC2=C(C(O)=O)C(O)=CC3=CC=CC=C23)C2=CC=CC=C2C=C1O

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(-20℃)

With Ice Pack

≥ 2 years